Iodinated density gradient media: a practical approach

Density gradient media for the purification of cells – a perspective

1. Iodinated density gradient media a historical perspective 1a. Metrizoate and diatrizoate In the nineteen-sixties, Nyegaard (later Nycomed) in Oslo began producing X-ray imaging agents that were derivatives of tri-iodobenzoic acid. Metrizoate (produced under the trade name IsopaqueTM) was one of the early versions of these tri-iodobenzoic acid derivatives (Figure 1). At about the same time, c...

A practical approach to transferring linear gradient elution methods.

Attempts to theoretically address the problems involved in transferring linear gradient elution methods have been somewhat ad hoc due to the simplifying assumptions usually made in conventional gradient elution theory. Until now, all equations based on the k* parameter of linear gradient elution theory used as the basis for predicting the separation selectivity have not explicitly included the ...

Iodinated contrast media and their adverse reactions.

Cross-use of technology between nuclear medicine and radiology technologists is expanding. The growth of PET/CT and the increasing use of intravenous contrast agents during these procedures bring the nuclear medicine technologist into direct contact with these agents and their associated complications. A basic understanding of the occurrence, risk factors, clinical features, and management of t...

Allergic Immediate Hypersensitivity to Iodinated Contrast Media

Background: Immediate hypersensitivity reactions (IHR) to iodinated contrast media (ICM) have traditionally been considered nonallergic; however, the increasingly frequent reporting of positive skin test and basophil activation test results suggests a specifi c allergic mechanism in some patients. Skin tests have been proposed as a useful tool for diagnosis, although their sensitivity and predi...

Iodinated porphyrins in contrast media agents: a new approach, first indicators